New Evolysse™ Form and Smooth Fillers for Smile Lines & Nasolabial Folds
| ABCS
Evolus expanded beyond its neuromodulator Jeuveau® (“Newtox”) with the launch of its first hyaluronic acid-based dermal fillers: Evolysse™ Form and Evolysse™ Smooth earlier this year. Both products are FDA-approved for the treatment of moderate to severe nasolabial folds and smile lines and join a competitive category that includes established products like Juvéderm®, Restylane®, and RHA®.
What are Evolysse™ Form and Smooth?
Evolysse™ Form and Evolysse™ Smooth are injectable fillers that use hyaluronic acid (HA) to add natural-looking volume and smooth lines and wrinkles in treated areas. According to their manufacturer, Evolus, what sets these products apart is a proprietary crosslinking and preservation process that maintains the natural structure of the HA.
- Evolysse™ Form provides a firmer, more structured consistency for deep folds and more pronounced volume loss.
- Evolysse™ Smooth offers a softer, more flexible formulation intended for finer lines and more superficial volume restoration.
Both fillers are designed to provide natural-looking improvements in facial expression zones such as smile lines and the nasolabial folds (the creases running from the sides of the nose to the corners of the mouth).
The American Board of Cosmetic Surgery (ABCS) closely monitors new injectable technologies to help patients make informed choices.
How long do results last?
Based on the clinical data reviewed for FDA approval, the results of Evolysse™ fillers typically last around 6 to 12 months and depend on the product used, the area treated, and the patient’s individual metabolism.
This duration range is similar to other HA-based fillers; however, Evolus notes that their proprietary technology may allow for improved longevity and durability.

How do Evolysse™ fillers compare to other HA fillers?
Evolysse™ Form and Smooth fall into a category of modern fillers that aim to balance resilience with flexibility.
Compared to other leading HA fillers:
- They use a proprietary manufacturing process that differentiates them from products made with older technologies.
- In FDA studies, they demonstrated non-inferiority to Restylane-L, a commonly used benchmark filler for similar concerns.
- Evolysse™ products can also be dissolved with hyaluronidase in the event of overcorrection, misplaced filler, or rare vascular complications.
Patient and provider feedback will be essential in evaluating long-term performance as the products become more widely available.
Injectable treatments performed by cosmetic surgeons who are certified by the ABCS are administered under the highest safety standards for optimal results.
Who is a candidate for Evolysse™ Form or Smooth?
Patients seeking an injectable smoothing treatment for lines around the mouth and lower face may benefit from these new options. Consult with a board certified cosmetic surgeon about your HA filler options if you:
- Want to soften the appearance of nasolabial folds or marionette lines
- Prefer a treatment with minimal downtime
- Are seeking natural-looking results that move well with facial expressions
- May be new to filler or are open to trying a different brand than what they’ve used before
As with all injectable treatments, safety and results depend heavily on the experience and training of the injector and should only be administered by qualified professionals under appropriate clinical protocols.
Those interested in Evolysse™ Form or Smooth or similar fillers should meet with a board certified cosmetic surgeon who has advanced knowledge of facial anatomy and extensive experience with a range of filler products to achieve optimal results. Find an ABCS board-certified cosmetic surgeon near you »